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Drugs and doses37

A–C Acetaminophen, Adenosine, Albuterol, Albuterol-Ipratropium, Amiodarone, Aspirin, Atropine, B-528

Acetaminophen

Indication	Population	Dose	Route	Repeat	Standing	Source
Mild to moderate pain	adult	1000 mg	IV/IO	not captured	standing	pages 24, 42, 57, 73
Mild to moderate pain	peds	15 mg/kg	IV/IO	not captured	standing	pages 24, 42, 57, 73
Sepsis	adult	1000 mg	IV	not captured	standing	page 66
Sepsis	peds	15 mg/kg	IV	not captured	standing	page 66

Adenosine

Indication	Population	Dose	Route	Repeat	Standing	Source
SVT	adult	6 mg	IV	not captured	standing	pages 95, 96
SVT	peds	0.1 mg/kg	IV	not captured	standing	pages 95, 96
Wide-complex tachycardia	adult	6 mg	IV	not captured	standing	page 96
Wide-complex tachycardia	peds	0.1 mg/kg	IV	not captured	standing	page 96

Albuterol

Indication	Population	Dose	Route	Repeat	Standing	Source
Allergic reaction	adult	2.5 mg	NEB	not captured	standing	page 20
Allergic reaction	peds	2.5 mg	NEB	not captured	standing	page 20
Asthma / bronchospasm	adult	2.5–5 mg	NEB	not captured	standing	page 26
Asthma / bronchospasm	peds	2.5 mg	NEB	not captured	standing	page 26

Albuterol-Ipratropium

Indication	Population	Dose	Route	Repeat	Standing	Source
Allergic reaction	adult	2.5 mg	NEB	not captured	standing	pages 20, 26
Allergic reaction	peds	2.5 mg	NEB	not captured	standing	pages 20, 26
Asthma / bronchospasm	adult	2.5 mg	NEB	not captured	standing	page 26
Asthma / bronchospasm	peds	2.5 mg	NEB	not captured	standing	page 26

Amiodarone

Indication	Population	Dose	Route	Repeat	Standing	Source
Wide-complex tachycardia	adult	150 mg	IV	not captured	standing	pages 96, 108
VF / pulseless VT	adult	300 mg	IV/IO	not captured	standing	pages 88, 105
VF / pulseless VT	peds	5 mg/kg	IV/IO	not captured	standing	pages 88, 105

Aspirin

Indication	Population	Dose	Route	Repeat	Standing	Source
ACS / chest pain	adult	324 mg	PO	not captured	standing	page 80

Atropine

Indication	Population	Dose	Route	Repeat	Standing	Source
Bradycardia	adult	1 mg	IV/IO	not captured	standing	page 91
Bradycardia	peds	0.02 mg/kg	IV/IO	not captured	standing	page 91
Organophosphate poisoning	adult	2–5 mg	IV	not captured	standing	page 59

B-52

Indication	Population	Dose	Route	Repeat	Standing	Source
Other	adult	50 mg	IV	not captured	standing	page 61

D–F Dextrose, Diazepam, Diphenhydramine, Dopamine, Epinephrine, Etomidate, Fentanyl7

Dextrose

Indication	Population	Dose	Route	Repeat	Standing	Source
Hypoglycemia	adult	12.5–25 g	IV	not captured	standing	pages 23, 44, 63, 75
Hypoglycemia	adult	25 g	IV/IO	not captured	standing	pages 44, 63
Hypoglycemia	peds	1 g/kg	IV	not captured	standing	pages 23, 44, 63, 75
Hypoglycemia	peds	25 g	IV/IO	not captured	standing	pages 44, 63

Diazepam

Indication	Population	Dose	Route	Repeat	Standing	Source
Mild to moderate pain	adult	2–5 mg	IV/IM	not captured	standing	pages 24, 42
Mild to moderate pain	peds	0.05–0.2 mg/kg	IV/IM	not captured	standing	pages 24, 42
Seizure	adult	2 mg	IV	not captured	standing	page 63
Seizure	adult	5–10 mg	IM	not captured	standing	pages 61, 63
Seizure	peds	0.1–0.3 mg/kg	PR	not captured	standing	page 63
Seizure	peds	0.2–0.4 mg/kg	IV	not captured	standing	page 63

Diphenhydramine

Indication	Population	Dose	Route	Repeat	Standing	Source
Allergic reaction	adult	25–50 mg	IV/IM	not captured	standing	page 20
Allergic reaction	peds	1 mg/kg	IV/IM	not captured	standing	page 20
Nausea / vomiting	adult	25–50 mg	IV	not captured	standing	page 48
Nausea / vomiting	peds	0.5–1 mg/kg	IV	not captured	standing	page 48
Other	adult	50 mg	IV	not captured	standing	page 61

Dopamine

Indication	Population	Dose	Route	Repeat	Standing	Source
Bradycardia	adult	2–20 mcg/kg	IV/IO	not captured	standing	pages 91, 93
Cardiogenic shock	adult	2–20 mcg/kg	IV/IO	not captured	standing	pages 66, 91, 93

Epinephrine

Indication	Population	Dose	Route	Repeat	Standing	Source
Anaphylaxis	adult	0.3–0.5 mg	IM	not captured	standing	pages 20, 27
Anaphylaxis	adult	0.3–0.5 mg	IV	not captured	standing	page 20
Anaphylaxis	peds	0.01 mg/kg	IM	not captured	standing	pages 20, 27
Bradycardia	adult	2–10 mcg	IV/IO	not captured	standing	pages 91, 106, 107
Bradycardia	peds	0.01 mg/kg	IV/IO	not captured	standing	pages 91, 106, 107
Cardiac arrest	adult	1 mg	IV/IO	not captured	standing	pages 85, 87, 88, 105, 106
Cardiac arrest	peds	0.01 mg/kg	IV/IO	not captured	standing	pages 85, 87, 88, 105, 106

Etomidate

Indication	Population	Dose	Route	Repeat	Standing	Source
Other	adult	0.3 mg/kg	IV	not captured	standing	page 38
Other	peds	0.3 mg/kg	IV	not captured	standing	page 38

Fentanyl

Indication	Population	Dose	Route	Repeat	Standing	Source
Mild to moderate pain	adult	25–100 mcg	IV/IN	not captured	standing	pages 18, 24, 29, 31, 42, 57, 73, 83
Post-intubation sedation	adult	0.5 mcg/kg	IV/IO	not captured	standing	page 38

G–L Glucagon, Haloperidol, Heparin, Ipratropium, Ketamine, Labetalol, Lidocaine, Lorazepam8

Glucagon

Indication	Population	Dose	Route	Repeat	Standing	Source
Hypoglycemia	adult	1 mg	IM	not captured	standing	pages 23, 44, 63, 75
Hypoglycemia	peds	0.5 mg	IM	not captured	standing	pages 23, 44, 63, 75

Haloperidol

Indication	Population	Dose	Route	Repeat	Standing	Source
Other	adult	5–10 mg	IM	not captured	standing	page 61

Heparin

Indication	Population	Dose	Route	Repeat	Standing	Source
STEMI	adult	60 unit/kg	IV	not captured	standing	page 82

Ipratropium

Indication	Population	Dose	Route	Repeat	Standing	Source
Allergic reaction	adult	0.5 mg	NEB	not captured	standing	page 20
Asthma / bronchospasm	adult	0.5 mg	NEB	not captured	standing	page 20

Ketamine

Indication	Population	Dose	Route	Repeat	Standing	Source
Other	adult	0.5–2 mg/kg	IV	not captured	standing	page 38
Other	adult	1–2 mg/kg	IV	not captured	standing	page 61
Other	peds	0.5–1 mg/kg	IV	not captured	standing	page 38
Mild to moderate pain	adult	0.1–0.3 mg/kg	IV/IO	not captured	standing	pages 18, 24, 29, 31, 42, 57, 74
Mild to moderate pain	peds	0.1–0.3 mg/kg	IV/IO	not captured	standing	pages 18, 24, 29, 31, 42, 57, 74
Post-intubation sedation	adult	0.5 mg/kg	IV	not captured	standing	page 38

Labetalol

Indication	Population	Dose	Route	Repeat	Standing	Source
Other	adult	20 mg	IV/IO	not captured	standing	page 45

Lidocaine

Indication	Population	Dose	Route	Repeat	Standing	Source
Cardiac arrest	adult	1–1.5 mg/kg	IV/IO	not captured	standing	pages 89, 90, 101
Cardiac arrest	peds	1 mg/kg	IV/IO	not captured	standing	pages 89, 90, 101
Other	adult	40 mg	IO	not captured	standing	page 146
Other	peds	0.5 mg/kg	IO	not captured	standing	page 146

Lorazepam

Indication	Population	Dose	Route	Repeat	Standing	Source
Other	adult	2 mg	IV	not captured	standing	page 61
Mild to moderate pain	adult	2 mg	IV/IM/IN	not captured	standing	pages 24, 42, 57
Mild to moderate pain	peds	0.05–0.1 mg/kg	IV/IM/IN	not captured	standing	pages 24, 42, 57
Seizure	adult	1–2 mg	IV/IM	not captured	standing	pages 61, 63
Seizure	peds	0.05–0.1 mg/kg	IV/IM	not captured	standing	pages 61, 63

M–O Magnesium Sulfate, Methylprednisolone, Midazolam, Morphine, Naloxone, Nitroglycerin, Ondansetron, Oral Glucose8

Magnesium Sulfate

Indication	Population	Dose	Route	Repeat	Standing	Source
Allergic reaction	adult	2 g	not captured	not captured	standing	page 20
Allergic reaction	peds	40 mg/kg	not captured	not captured	standing	page 20
Asthma / bronchospasm	adult	2 g	IV/IO	not captured	standing	page 27
Asthma / bronchospasm	peds	40 mg/kg	IV/IO	not captured	standing	page 27
Eclampsia / pre-eclampsia	adult	4 g	IV	not captured	standing	page 52
Other	adult	1–2 g	IV	not captured	standing	page 52

Methylprednisolone

Indication	Population	Dose	Route	Repeat	Standing	Source
Allergic reaction	adult	125 mg	IV/IM	not captured	standing	page 20
Allergic reaction	peds	1 mg/kg	IV/IM	not captured	standing	page 20
Asthma / bronchospasm	adult	125 mg	IV/IM	not captured	standing	page 27
Asthma / bronchospasm	peds	1 mg/kg	IV/IM	not captured	standing	page 27

Midazolam

Indication	Population	Dose	Route	Repeat	Standing	Source
Alcohol withdrawal	adult	0.5–2.5 mg	IV/IM/IN	not captured	standing	page 19
Alcohol withdrawal	peds	0.05–0.1 mg/kg	IV/IM/IN	not captured	standing	page 19
Mild to moderate pain	peds	0.05–0.1 mg/kg	IV/IM/IN	not captured	standing	pages 24, 29, 31, 42, 57, 73
Post-intubation sedation	adult	2–5 mg	IV	not captured	standing	page 108
Post-intubation sedation	peds	0.3 mg/kg	IV	not captured	standing	page 108
Procedural sedation	adult	2–2.5 mg	IV/IO/IM/IN	not captured	standing	page 184
Seizure	adult	2–5 mg	IV/IM/IN	not captured	standing	page 63
Seizure	peds	0.1 mg/kg	IV/IM/IN	not captured	standing	page 63

Morphine

Indication	Population	Dose	Route	Repeat	Standing	Source
Mild to moderate pain	adult	2–4 mg	IV	not captured	standing	pages 18, 24, 29, 31, 42, 57, 73, 82, 83

Naloxone

Indication	Population	Dose	Route	Repeat	Standing	Source
Opioid overdose	adult	1–2 mg	IV/IO/IM/IN/ET	not captured	standing	page 58
Opioid overdose	adult	1–4 mg	IN	not captured	standing	page 58
Opioid overdose	adult	1–4 mg	IV/IM/IN	not captured	standing	page 75
Opioid overdose	peds	1–4 mg	IV/IM/IN	not captured	standing	page 75
Mild to moderate pain	adult	1–4 mg	IV/IN	not captured	standing	page 57

Nitroglycerin

Indication	Population	Dose	Route	Repeat	Standing	Source
ACS / chest pain	adult	0.4 mg	SL	not captured	standing	pages 80, 81, 82, 84
CHF / pulmonary edema	adult	0.4 mg	SL	not captured	standing	page 27
Other	adult	0.4 mg	SL	not captured	standing	page 45

Ondansetron

Indication	Population	Dose	Route	Repeat	Standing	Source
Nausea / vomiting	adult	4 mg	IV/PO	not captured	standing	pages 18, 19, 48

Oral Glucose

Indication	Population	Dose	Route	Repeat	Standing	Source
Hypoglycemia	adult	15 g	PO	not captured	standing	pages 23, 44
Hypoglycemia	peds	0.5 g/kg	PO	not captured	standing	pages 23, 44

P–R Racemic Epinephrine, Rocuronium2

Racemic Epinephrine

Indication	Population	Dose	Route	Repeat	Standing	Source
Croup	peds	0.5 mL	NEB	not captured	standing	page 27

Rocuronium

Indication	Population	Dose	Route	Repeat	Standing	Source
RSI paralysis	adult	0.6–1.2 mg/kg	IV	not captured	standing	page 38
RSI paralysis	peds	0.6–1.2 mg/kg	IV	not captured	standing	page 38

S–Z Sodium Bicarbonate, Succinylcholine, Ticagrelor, Tranexamic Acid4

Sodium Bicarbonate

Indication	Population	Dose	Route	Repeat	Standing	Source
Cardiac arrest	adult	50 mL	IV/IO	not captured	standing	pages 85, 100
Cardiac arrest	peds	1 mEq/kg	IV/IO	not captured	standing	pages 85, 100
Crush injury	adult	100 mEq	IV/IO	not captured	standing	page 74
Crush injury	peds	1 mEq/kg	IV/IO	not captured	standing	page 74
Tricyclic overdose	adult	100 mEq	IV	not captured	standing	page 59
Tricyclic overdose	peds	1 mEq/kg	IV	not captured	standing	page 59

Succinylcholine

Indication	Population	Dose	Route	Repeat	Standing	Source
RSI paralysis	adult	1–1.5 mg/kg	IV	not captured	standing	page 38
RSI paralysis	peds	1–1.5 mg/kg	IV	not captured	standing	page 38

Ticagrelor

Indication	Population	Dose	Route	Repeat	Standing	Source
STEMI	adult	180 mg	PO	not captured	standing	page 82

Tranexamic Acid

Indication	Population	Dose	Route	Repeat	Standing	Source
Trauma / hemorrhage	adult	1000 mg	IV	not captured	standing	pages 24, 74

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